Vaccines, Reverse Vaccinology, and Bacterial Pathogenesis
نویسندگان
چکیده
منابع مشابه
Vaccines, reverse vaccinology, and bacterial pathogenesis.
Advances in genomics and innovative strategies such as reverse vaccinology have changed the concepts and approaches to vaccine candidate selection and design. Genome mining and blind selection of novel antigens provide a novel route to investigate the mechanisms that underpin pathogenesis. The resulting lists of novel candidates are revealing new aspects of pathogenesis of target organisms, whi...
متن کاملReverse vaccinology.
Whole-genome sequencing of bacteria and advances in bioinformatics have revolutionized the vaccinology field, leading to the identification of potential vaccine candidates without the need for cultivating the pathogen. This approach, termed "reverse vaccinology", reduces the time and cost required for the identification of candidate vaccines and provides new solutions for those diseases for whi...
متن کاملDeveloping vaccines in the era of genomics: a decade of reverse vaccinology.
Vaccines have a significant impact on public health, and vaccinology in the era of genomics is taking advantage of new technologies to tackle diseases for which vaccine development has so far been unsuccessful. Almost all existing vaccines were developed based on traditional vaccinology methods, which relied on empirical screening of a few candidates at a time, based on known features of the pa...
متن کاملNERVE: New Enhanced Reverse Vaccinology Environment
BACKGROUND Since a milestone work on Neisseria meningitidis B, Reverse Vaccinology has strongly enhanced the identification of vaccine candidates by replacing several experimental tasks using in silico prediction steps. These steps have allowed scientists to face the selection of antigens from the predicted proteome of pathogens, for which cell culture is difficult or impossible, saving time an...
متن کاملEvidence-based vaccinology: the work of the Cochrane Vaccines Field.
The volume of vaccine analytical literature is notable (the journal Vaccine alone having published 231 trials on diVerent vaccines between 1983 and 1994 ). However, to date little attention has been paid to summarising and evaluating its significance in the assessment of vaccine quality (defined as eYcacy, eVectiveness, eYciency, safety, and acceptability). Quality assessment is important as va...
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ژورنال
عنوان ژورنال: Cold Spring Harbor Perspectives in Medicine
سال: 2013
ISSN: 2157-1422
DOI: 10.1101/cshperspect.a012476